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Researcher, Lecturer in Chemical and Biomolecular Engineering, Applied Mechanics of Tumors, Polymer and Sol-Gel Science, Membranes, Cryo SEM, Mathematical Modeling, Optics at Johns Hopkins University


Sai S. Prakash, M.S., Ph.D., Sr. Research Scientist in Physics of Soft and Biological Matter, Physics of Cancer; Polymers, Membranes; Cryo SEM, Ellipsometry; Mathematical Modeling; Lecturer in Engineering




  • Ph.D., 2001, Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA
  • M.S., 1995, Chemical Engineering and Materials Science, University of New Mexico, Albuquerque, NM, USA
  • B.Tech. (B.S.), 1993, Chemical Engineering, Indian Institute of Technology, Mumbai (Bombay), India

Research Areas

Scientific researcher (ResearcherID: A-3459-2010) and project leader/manager in Polymers, Membrane/Coating Science for Water, Electronics, Medicine:

  • Applied mechanics, physics of tumor microenvironments; Multiphysics modeling with Comsol (finite element analysis); Cryo HRSEM for biology and medicine: Collaboration with Brady Urological Institute, School of Medicine, Johns Hopkins University
  • Nanostructured membranes via colloid-polymer interfacial engineering and biomimicry
  • Visualization of evolving microphases or colloidal assemblies in polymeric membranes, hydrogels via cryogenic scanning electron microscopy (cryo-SEM)
  • Theoretical modeling of multicomponent diffusion, heat transfer and thermodynamics in phase inversion membrane formation
  • Fluid dynamical analyses of particle filtration in porous media using mechanistic and probabilistic approaches and Stokesian flows
  • Chemical synthesis and in situ optical imaging (ellipsometry) of ambient pressure aerogel films prepared via sol-gel process
  • Experimental techniques – Cryo HRSEM, ESEM, AFM, ATR-FTIR, Imaging Ellipsometry
  • Computational methods – Matlab (finite differences), Comsol, Mathematica
Highlights, Summary
  • Multiphysics modeling of macroscopic “mechano-metabolomics” in relation to oncogenesis, homeorhesis, cancer invasion and metastasis; computationally identified “histo-dynamics”; constructal law; transdisciplinary research in physics, engineering, and oncology
  • Captured conclusive visual evidence of microstructural evolution in phase separation membranes using time-sectioning cryo-SEM, and proposed critical theory on pore structure and macrovoid formation using poroelasticity, during Ph.D., to resolve 50-year old problem in membrane science
  • Co-invented breakthrough ambient pressure process to prepare aerogel films, during M.S., circumventing 60-year old hazardous route
  • 8.5 years experience in research leadership and management in global filtration industry: experimental polymer science applied to membrane technology, theoretical modeling with coupled nonlinear PDEs, industry-academe innovations (with MIT, NIST, Sandia NL, Cornell)
  • 3 years experience in teaching chemical and biomolecular engineering courses at JHU: 6 undergraduate-level courses, 3 classes per semester
  • Top two highly-cited articles have 202 and 95 citations in Web of Science, 264 and 149 in Google Scholar, respectively

 Lecturer in Chemical and Biomolecular Engineering at Johns Hopkins University:

  • Fall: 540.409, Modeling, Dynamics and Control in Chemical and Biological Systems
  • Fall: 540.311/313, Chemical and Biomolecular Engineering Laboratory
  • Spring: 540.314, Chemical Engineering Product and Process Design
  • Spring: 540.303, Transport Phenomena I
  • Spring: 540.203, Engineering Thermodynamics
  • Spring: 540.202, Chemical and Biological Process Analysis
Key Publications, Abstracts
  1. S.S. Prakash, “Physicochemical Modeling of Tumorigenic Homeorhesis: A System-Dynamics Interpretation of Computer Simulations,” Convergent Science Physical Oncology, 2 (2016) 035001, 1-17.
  2. S.S. Prakash, "Cavitation of Tumoral Basement Membrane as Onset of Cancer
    invasion and metastasis: physics of oncogenic homeorhesis via
     Invasion and Metastasis: Physics of Oncogenic Homeorhesis via Nonlinear Mechano-Metabolomics," Convergent Science Physical Oncology, 2 (2016) 015001, 1-24.
  3. S.S. Prakash, "From 'Fracking' and 'Macrovoids' to the Onset of Cancer Metastasis: A Mechano-Metabolomics Model of a Plausible Fluid-Solid Network Instability in Tumors," at the Neuroengineering, Neural Systems/Biophysics and Modelling session of the World Congress on Medical Physics and Biomedical Engineering, International Union of Physical and Engineering Sciences in Medicine (IUPESM) June 2015 at Toronto, ON, Canada. pdf
  4. S.S. Prakash, "Does Tensile Rupture of Tumor Basement Membrane Mark the Onset of Cancer Metastasis?" at the Physics of Cancer session, American Physical Society (APS) March 2015 Meeting at San Antonio, TX. abs
  5. S.S. Prakash, L.F. Francis and L.E. Scriven, "Microstructure Evolution in Dry-Wet Cast Polysulfone Membranes by Cryo-SEM: A Hypothesis on Macrovoid Formation," J. Membrane Science, 313:1-2, (2008), 135-157. Erratum: 320:1-2, (2008), 557.
  6. S.S. Prakash, L.F. Francis and L.E. Scriven, "Microstructure Evolution in Dry Cast Cellulose Acetate Membranes by Cryo-SEM," J. Membrane Science, 283:1-2, (2006), 328-338.
  7. S.S. Prakash, L.F. Francis, and L.E. Scriven, "Time-sectioning Cryo-SEM Evidence of the Mechanism of Macrovoid Formation in Phase Inversion Membranes," Proceedings of the 14th Annual Meeting of the North American Membrane Society, Jackson Hole, WY, 17-21 May 2003. pdf
  8. S.S. Prakash, C.J. BrinkerA.J. Hurd and S.M. Rao, "Silica Aerogel Films at Ambient Pressure via Surface Derivatization and Reversible Drying Shrinkage," Nature, 374, (1995), 439-443.  Erratum: 375, (1995), 431. 
  9. S.S. Prakash, C.J. Brinker, and A.J. Hurd, "Ambient Pressure Silica Aerogel Films," J. Non-Crystalline Solids, 190, (1995), 264-275.
  10. C.J. Brinker and S.S. Prakash, "Ambient Pressure Process for Preparing Aerogel Thin Films / Reliquified Sols Useful in Preparing Aerogel Thin Films," US Patent SN 5,948,482, (1999).
For complete list of publications and oral presentations, click here.

Email: [email protected], [email protected]


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